National Polytechnic College is institutionally accredited by the Accrediting Commission of Career Schools and Colleges (ACCSC), which is listed by the U.S. Department of Education as a nationally recognized accrediting agency.

National Polytechnic College is a private institution, approved to operate by the Bureau for Private Postsecondary Education (BPPE)

The English as a Second Language courses are programmatically accredited by the Commission on English Language Program Accreditation (CEA

The Hemodialysis Technician and Phlebotomy Technician programs are programmatically approved by the California Department of Public Health, (CDPH)

The MRI Technologist program is programmatically accredited by the American Registry of Magnetic Resonance Imaging Technologist (ARMRIT)

The MRI Technologist and Diagnostic Medical Sonography programs are recognized by the American Registry of Radiologic Technologists (ARRT)